GOSH has been at the forefront of Paediatric medicine for more than a century and a half. In 1967, Great Ormond Street Hospital led the first UK clinical trials of the rubella vaccine. In 1970, the UK-wide immunisation of girls and childbearing adult females was rolled out for rubella. In 1979, GOSH surgeon, Professor Levinsky saved the life of Andrew Williams in a landmark procedure, the first bone marrow transplant carried out in the UK. More recently, in 2000, Great Ormond Street Hospital launched the world’s first gene therapy trials for children born without functioning immune systems. By 2011, gene therapy had cured 14 children with previously fatal forms of severe combined immunodeficiency. With help Great Ormond Street plans to continue to push boundaries with new and improved treatments and open a new clinical building, housing a surgery centre, a 16-bed isolation facility, a post-anaesthetic care unit, new neurosciences beds and modern inpatient facilities for children with respiratory conditions.